Flexeril ve Perphenazine and amitriptyline
Flexeril ve Perphenazine and amitriptyline etkileşiminin ve ortak uygulama olasılığının belirlenmesi.
Hizmeti oluşturmak için kullanılan resmi rehberlerin veritabanında, hasta için olumsuz sağlık etkilerine yol açabilecek veya karşılıklı yararlı etkiyi artırabilecek istatistiksel olarak araştırma ile kaydedilen etkileşim tespit edilmiştir. İlaçların birlikte uygulanması konusunda bir doktora danışılması gerekir.
Tüketici:Birlikte cyclobenzaprine ile amitriptilin kullanarak kalp hızı, ateş, aşırı terleme arttı, titreme ya da bulanık görme, kas spazmları veya sertlik, titreme, koordinasyon bozukluğu, mide krampı, bulantı, kusma, ishal ve titreme gibi konfüzyon kan basıncı, halüsinasyon, nöbet, aşırı değişiklikler gibi belirtiler içerebilir serotonin sendromu denilen nadir fakat ciddi bir hastalık riskini artırabilir. Ağır vakalarda, koma ve hatta ölüme neden olabilir. Eğer ilaç alırken bu belirtileri yaşarsanız acil tıbbi yardım isteyin gerekir. Eğer herhangi bir sorunuz veya endişeniz varsa doktorunuzla konuşun. Doktorunuz zaten risklerin farkında olabilir, ama bu sizin için en iyi tedavi olduğunu belirlemiş ve gerekli önlemleri almıştır ve yakından herhangi bir potansiyel komplikasyonlar için izleme. Kullandığınız diğer tüm ilaçlar, vitaminler ve otlar da dahil olmak üzere doktorunuza başvurun önemlidir. Önce doktorunuza danışmadan herhangi bir ilaç kullanarak durdurmak.
Profesyonel:MONİTÖRÜ YAKINDAN: bu tür serotonin geri alım inhibitörleri, monoamin oksidaz inhibitörleri, trisiklik antidepresanlar, 5-HT1 reseptör agonistleri, ergot alkoloidler, cyclobenzaprine, lityum, sarı kantaron, phenylpiperidine fentanil, dekstrometorfan gibi serotonerjik aktivite ile ajanlarla beraber kullanımı, beyin sapı ve triptofan 5-HT1A ve 2A reseptörleri hiperstimülasyon sonucu düşünülen nadir ancak ciddi ve potansiyel olarak ölümcül bir durum olan serotonin sendromu riskini artırabilir. Serotonin sendromu semptomları; örneğin karın ağrısı, bulantı, kusma gibi taşikardi, hipertermi, terleme, titreme, kan basıncı kontrolü gibi otonomik disfonksiyon ve mydriasis; bu hiperrefleksi, kronik kas spazmı, titreme, katılık ve ataksi gibi nöromüsküler anormallikler; ve gastrointestinal belirtiler, ishal, sinirlilik, değişmiş bilinç, bilinç bulanıklığı, halüsinasyon gibi zihinsel durum değişiklikleri ve koma.
YÖNETİMİ: genel Olarak, birden fazla serotonerjik ajanlarla beraber kullanılması mümkünse, ya da aksi takdirde potansiyel yarar riskten daha fazla kabul edilir Eğer dikkatle ele kaçınılmalıdır. Bazı hastalar tedavi sırasında serotonin sendromu belirtileri için izlenmelidir. Özellikle dikkat bu ajanların doz artırılması önerilir. Serotonin sendromu için potansiyel risk bazı ajanlar uzun süreli eliminasyon yarı-ömrü gösterebilir gibi sırayla serotonerjik ajanlar yönetirken bile kabul edilmelidir. Örneğin, bazı uzmanlar başka bir serotonerjik ajan uygulamadan önce vortioxetine kullanımını takiben fluoksetin ve 3 hafta kullanın aşağıdaki geçtikten haftada 5 öneririm. Arınma dönemleri için ayrı ürün etiketleme mevcut öneriler için bakılmalıdır. Eğer serotonin sendromu oluşursa veya tedavi sırasında şüpheli, tüm serotonerjik ajanlar derhal kesilmeli ve destekleyici bakım olarak gerekli kılmıştır. Orta derecede hastalığı olan hastaları da (örneğin, difenhidramin, klorpromazin) serotonin antagonisti yönetiminden yararlanabilirsiniz. Ciddi durumlarda bir Toksikoloji uzmanı ile istişare altında yönetilmelidir ve diğer önlemlerin yanı sıra sedasyon, nöromüsküler paralizi, entübasyon ve mekanik ventilasyon gerekebilir.
- Paruchuri P, Godkar D, Anandacoomarswamy D, Sheth K, Niranjan S "Rare case of serotonin syndrome with therapeutic doses of paroxetine." Am J Ther 13 (2006): 550-552
- Dougherty JA, Young H, Shafi T "Serotonin syndrome induced by amitriptyline, meperidine, and venlafaxine." Ann Pharmacother 36 (2002): 1647-1648
- "Product Information. Brintellix (vortioxetine)." Takeda Pharmaceuticals America, Lincolnshire, IL.
- Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8
- George TP, Godleski LS "Possible serotonin syndrome with trazodone addition to fluoxetine." Biol Psychiatry 39 (1996): 384-5
- Ruiz F "Fluoxetine and the serotonin syndrome." Ann Emerg Med 24 (1994): 983-5
- Thomas CR, Rosenberg M, Blythe V, Meyer WJ 3rd "Serotonin syndrome and linezolid." J Am Acad Child Adolesc Psychiatry 43 (2004): 790
- Rang ST, Field J, Irving C "Serotonin toxicity caused by an interaction between fentanyl and paroxetine." Can J Anaesth 55 (2008): 521-5
- Bergeron L, Boule M, Perreault S "Serotonin toxicity associated with concomitant use of linezolid." Ann Pharmacother 39 (2005): 956-61
- "Product Information. Cymbalta (duloxetine)." Lilly, Eli and Company, Indianapolis, IN.
- "Product Information. Zoloft (sertraline)." Roerig Division, New York, NY.
- "Product Information. Viibryd (vilazodone)." Trovis Pharmaceuticals LLC, New Haven, CT.
- "Product Information. Maxalt (rizatriptan)." Merck & Co, Inc, West Point, PA.
- Morales N, Vermette H "Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine." Psychosomatics 46 (2005): 274-5
- Skop BP, Finkelstein JA, Mareth TR, Magoon MR, Brown TM "The serotonin syndrome associated wtih paroxetine, an over-the-counter cold remedy, and vascular disease." Am J Emerg Med 12 (1994): 642-4
- "Product Information. Zomig (zolmitriptan)." Zeneca Pharmaceuticals, Wilmington, DE.
- Hammerness P, Parada H, Abrams A "Linezolid: MAOI Activity and Potential Drug Interactions." Psychosomatics 43 (2002): 248-9
- "Product Information. Flexeril (cyclobenzaprine)." Merck & Co, Inc, West Point, PA.
- Gordon JB "SSRI's and St. John's Wort: possible toxicity?" Am Fam Physician 57 (1998): 950,953
- Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13
- Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions: I. Antidepressants and antipsychotics." J Clin Psychopharmacol 10 (1990): 48-50
- Nierenberg DW, Semprebon M "The central nervous system serotonin syndrome." Clin Pharmacol Ther 53 (1993): 84-8
- Morales-Molina JA, Mateu-de Antonio J, Marin-Casino M, Grau S "Linezolid-associated serotonin syndrome: what we can learn from cases reported so far." J Antimicrob Chemother 56 (2005): 1176-8
- Duggal HS, Fetchko J "Serotonin syndrome and atypical antipsychotics." Am J Psychiatry 159 (2002): 672-3
- Perry NK "Venlafaxine-induced serotonin syndrome with relapse following amitriptyline." Postgrad Med J 76 (2000): 254-6
- Rosebraugh CJ, floxkhart DA, Yasuda SU, Woosley RL "Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient." J Clin Pharmacol 41 (2001): 224-7
- Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6
- "Product Information. Nucynta (tapentadol)." PriCara Pharmaceuticals, Raritan, NJ.
- Roy S, Fortier LP "Fentanyl-induced rigidity during emergence from general anesthesia potentiated by venlafexine." Can J Anaesth 50 (2003): 32-5
- Nijhawan PK, Katz G, Winter S "Psychiatric illness and the serotonin syndrome: an emerging adverse drug effect leading to intensive care unit admission." Crit Care Med 24 (1996): 1086-9
- "Product Information. Fetzima (levomilnacipran)." Forest Pharmaceuticals, St. Louis, MO.
- DeBellis RJ, Schaefer OP, Liquori M, Volturo GA "Linezolid-associated serotonin syndrome after concomitant treatment with citalopram and mirtazepine in a critically ill bone marrow transplant recipient." J Intensive Care Med 20 (2005): 351-3
- Corkeron MA "Serotonin syndrome - a potentially fatal complication of antidepressant therapy." Med J Aust 163 (1995): 481-2
- Mackay FJ, Dunn NR, Mann RD "Antidepressants and the serotonin syndrome in general practice." Br J Gen Pract 49 (1999): 871-4
- "Product Information. Meridia (sibutramine)." Knoll Pharmaceutical Company, Whippany, NJ.
- Strouse TB, Kerrihard TN, Forscher CA, Zakowski P "Serotonin syndrome precipitated by linezolid in a medically ill patient on duloxetine." J Clin Psychopharmacol 26 (2006): 681-683
- Boyer EW, Shannon M "The serotonin syndrome." N Engl J Med 352 (2005): 1112-20
- "Product Information. D.H.E. 45 (dihydroergotamine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. Zyvox (linezolid)" Pharmacia and Upjohn, Kalamazoo, MI.
- Jones SL, Athan E, O'Brien D "Serotonin syndrome due to co-administration of linezolid and venlafaxine." J Antimicrob Chemother 54 (2004): 289-90
- "Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.
- Bhatara VS, Magnus RD, Paul KL, Preskorn SH "Serotonin syndrome induced by venlafaxine and fluoxetine: a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechanisms." Ann Pharmacother 32 (1998): 432-6
- Steinberg M, Morin AK "Mild serotonin syndrome associated with concurrent linezolid and fluoxetine." Am J Health Syst Pharm 64 (2007): 59-62
- "Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc, Marietta, GA.
- Lavery S, Ravi H, McDaniel WW, Pushkin YR "Linezolid and serotonin syndrome." Psychosomatics 42 (2001): 432-4
- Weiner AL "Meperidine as a potential cause of serotonin syndrome in the emergency department." Acad Emerg Med 6 (1999): 156-8
- Hachem RY, Hicks K, Huen A, Raad I "Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients." Clin Infect Dis 37 (2003): E8-E11
- "Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
- "Product Information. Savella (milnacipran)." Forest Pharmaceuticals, St. Louis, MO.
- Keegan MT, Brown DR, Rabinstein AA "Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs." Anesth Analg 103 (2006): 1466-8
- Baetz M, Malcolm D "Serotonin syndrome from fluvoxamine and buspirone." Can J Psychiatry 40 (1995): 428-9
- Tissot TA "Probable meperidine-induced serotonin syndrome in a patient with a history of fluoxetine use." Anesthesiology 98 (2003): 1511-1512
- Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763
- Ailawadhi S, Sung KW, Carlson LA, Baer MR "Serotonin syndrome caused by interaction between citalopram and fentanyl." J Clin Pharm Ther 32 (2007): 199-202
- Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5
- Mugele J, Nanagas KA, Tormoehlen LM "Serotonin Syndrome Associated With MDPV Use: A Case Report." Ann Emerg Med (2012):
- "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Pristiq (desvenlafaxine)." Wyeth Laboratories, Philadelphia, PA.
- Turkel SB, Nadala JG, Wincor MZ "Possible serotonin syndrome in association with 5-HT3 antagonist agents." Psychosomatics 42 (2001): 258-60
- Shapiro RE, Tepper SJ "The serotonin syndrome, triptans, and the potential for drug-drug interactions." Headache 47 (2007): 266-9
- Achamallah NS "Visual hallucinations after combining fluoxetine and dextromethorphan ." Am J Psychiatry 149 (1992): 1406
- Goldberg RJ, Huk M "Serotonin syndrome from trazodone and buspirone." Psychosomatics 33 (1992): 235-6
- Lantz MS, Buchalter E, Giambanco V "St. John's wort and antidepressant drug interactions in the elderly." J Geriatr Psychiatr Neurol 12 (1999): 7-10
- Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7
- Wigen CL, Goetz MB "Serotonin syndrome and linezolid." Clin Infect Dis 34 (2002): 1651-2
- Metz A "Interaction between fluoxetine and buspirone." Can J Psychiatry 35 (1990): 722-3
- Tahir N "Serotonin syndrome as a consequence of drug-resistant infections: an interaction between linezolid and citalopram." J Am Med Dir Assoc 5 (2004): 111-3
- Lane R, Baldwin D "Selective serotonin reuptake inhibitor--induced serotonin syndrome: review." J Clin Psychopharmacol 17 (1997): 208-21
- Insler SR, Kraenzler EJ, Licina MG, Savage RM, Starr NJ "Cardiac surgery in a patient taking monoamine oxidase inhibitors - an adverse fentanyl reaction." Anesth Analg 78 (1994): 593-7
- Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
- Harvey AT, Preskorn SH "Interactions of serotonin reuptake inhibitors with tricyclic antidepressants." Arch Gen Psychiatry 52 (1995): 783-4
- Laird LK "Issues in the monopharmacotherapy and polypharmacotherapy of obsessive-compulsive disorder." Psychopharmacol Bull 32 (1996): 569-78
- Insel TR, Roy BF, Cohen RM, Murphy DL "Possible development of the serotonin syndrome in man." Am J Psychiatry 139 (1982): 954-5
- Smith DL, Wenegrat BG "A case report of serotonin syndrome associated with combined nefazodone and fluoxetine." J Clin Psychiatry 61 (2000): 146
- Bernard L, Stern R, Lew D, Hoffmeyer P "Serotonin syndrome after concomitant treatment with linezolid and citalopram." Clin Infect Dis 36 (2003): 1197
- Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75
- Manos GH "Possible serotonin syndrome associated with buspirone added to fluoxetine." Ann Pharmacother 34 (2000): 871-4
- Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11
- Giese SY, Neborsky R "Serotonin syndrome: potential consequences of Meridia combined with Demerol or fentanyl." Plast Reconstr Surg 107 (2001): 293-4
- Mason BJ, Blackburn KH "Possible serotonin syndrome associated with tramadol and sertraline coadministration." Ann Pharmacother 31 (1997): 175-7
- "Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
- Gillman PK "Linezolid and serotonin toxicity." Clin Infect Dis 37 (2003): 1274-5
- Taylor JJ, Wilson JW, Estes LL "Linezolid and serotonergic drug interactions: a retrospective survey." Clin Infect Dis 43 (2006): 180-7
- Fischer P "Serotonin syndrome in the elderly after antidepressive monotherapy." J Clin Psychopharmacol 15 (1995): 440-2
- Margolese HC, Chouinard G "Serotonin syndrome from addition of low-dose trazodone to nefazodone." Am J Psychiatry 157 (2000): 1022
- Hunter B, Kleinert MM, Osatnik J, Soria E "Serotonergic syndrome and abnormal ocular movements: worsening of rigidity by remifentanil?" Anesth Analg 102 (2006): 1589
- "Product Information. Prozac (fluoxetine)." Dista Products Company, Indianapolis, IN.
- Lee J, Franz L, Goforth HW "Serotonin syndrome in a chronic-pain patient receiving concurrent methadone, ciprofloxacin, and venlafaxine." Psychosomatics 50 (2009): 638-9
- Dannawi M "Possible serotonin syndrome after combination of buspirone and St John's Wort." J Psychopharmacol 16 (2002): 401
- Noble WH, Baker A "MAO inhibitors and coronary artery surgery: a patient death." Can J Anaesth 39 (1992): 1061-6
- "Product Information. Oleptro (traZODone)." Labopharm Inc, Laval, AL.
- Hansen TE, Dieter K, Keepers GA "Interaction of fluoxetine and pentazocine." Am J Psychiatry 147 (1990): 949-50
- Packer S, Berman SA "Serotonin syndrome precipitated by the monoamine oxidase inhibitor linezolid." Am J Psychiatry 164 (2007): 346-7
- John L, Perreault MM, Tao T, Blew PG "Serotonin syndrome associated with nefazodone and paroxetine." Ann Emerg Med 29 (1997): 287-9
- "Product Information. Imitrex (sumatriptan)." Glaxo Wellcome, Research Triangle Park, NC.
- Mathew NT, Tietjen GE, Lucker C "Serotonin syndrome complicating migraine pharmacotherapy." Cephalalgia 16 (1996): 323-7
- Egberts AC, ter Borg J, Brodie-Meijer CC "Serotonin syndrome attributed to tramadol addition to paroxetine therapy." Int Clin Psychopharmacol 12 (1997): 181-2
- Reeves RR, Bullen JA "Serotonin syndrome produced by paroxetine and low-dose trazodone." Psychosomatics 36 (1995): 159-60
- Gardner DM, Lynd LD "Sumatriptan contraindications and the serotonin syndrome." Ann Pharmacother 32 (1998): 33-8
Jenerik adı: cyclobenzaprine
Marka adı: Amrix, Fexmid, Flexeril, Comfort Pac with Cyclobenzaprine
Eşdeğer ilaçlar: yok
Jenerik adı: amitriptyline / perphenazine
Marka adı: Etrafon Forte, Triavil, Etrafon 2-10, Etrafon 2-25
Eşdeğer ilaçlar: Amitriptyline and perphenazine, Amitriptyline and Perphenazine
İlaç uyumluluğu ve etkileşimlerinin kontrolü sürecinde, Drugs.com, Rxlist.com, Webmd.com ve Medscape.com rehberleri kullanılmıştır.
- Flexeril-Perrigo Benzoyl Peroxide Alcohol Base Gel
- Flexeril-Perrigo Benzoyl Peroxide Gel
- Flexeril-Perrigo Benzoyl Peroxide Wash
- Flexeril-Perrigo Sodium Sulfacetamide and Sulfur
- Flexeril-Persa-Gel
- Flexeril-Persantine
- Perphenazine and amitriptyline-Flextra
- Perphenazine and amitriptyline-Flextra 650
- Perphenazine and amitriptyline-Flibanserin
- Perphenazine and amitriptyline-Flintstones Complete
- Perphenazine and amitriptyline-Flintstones Gummies
- Perphenazine and amitriptyline-Flintstones Gummies Complete